Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats
| Autor: | Wang Yangkai, Yu Deng, Wei-Zhong Wang, Miao-Ling Li, Tan Xing |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Microdialysis Physiology Blood Pressure Peptidyl-Dipeptidase A Cardiovascular System 03 medical and health sciences 0302 clinical medicine Internal medicine Rats Inbred SHR Renin–angiotensin system medicine Animals business.industry General Neuroscience General Medicine Rostral ventrolateral medulla Acetylcholine Cholinergic Neurons Rats Atropine 030104 developmental biology Blood pressure Endocrinology Angiotensin-converting enzyme 2 Hypertension Cholinergic Original Article Angiotensin-Converting Enzyme 2 business 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists medicine.drug |
| Popis: | The rostral ventrolateral medulla (RVLM) is a key region in cardiovascular regulation. It has been demonstrated that cholinergic synaptic transmission in the RVLM is enhanced in hypertensive rats. Angiotensin-converting enzyme 2 (ACE2) in the brain plays beneficial roles in cardiovascular function in hypertension. The purpose of this study was to determine the effect of ACE2 overexpression in the RVLM on cholinergic synaptic transmission in spontaneously hypertensive rats (SHRs). Four weeks after injecting lentiviral particles containing enhanced green fluorescent protein and ACE2 bilaterally into the RVLM, the blood pressure and heart rate were notably decreased. ACE2 overexpression significantly reduced the concentration of acetylcholine in microdialysis fluid from the RVLM and blunted the decrease in blood pressure evoked by bilateral injection of atropine into the RVLM in SHRs. In conclusion, we suggest that ACE2 overexpression in the RVLM attenuates the enhanced cholinergic synaptic transmission in SHRs. |
| Databáze: | OpenAIRE |
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