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▴ Konstantinides S, Geibel A, Heusel G, et al . Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism. N Engl Med J2002;347:1143–50 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] This was a randomised placebo controlled trial of alteplase (100 mg over 2 hours) with heparin v placebo with heparin in 256 patients with submassive pulmonary embolism (PE) defined as … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DKonstantinides%26rft.auinit1%253DS.%26rft.volume%253D347%26rft.issue%253D15%26rft.spage%253D1143%26rft.epage%253D1150%26rft.atitle%253DHeparin%2Bplus%2BAlteplase%2BCompared%2Bwith%2BHeparin%2BAlone%2Bin%2BPatients%2Bwith%2BSubmassive%2BPulmonary%2BEmbolism%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa021274%26rft_id%253Dinfo%253Apmid%252F12374874%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa021274&link_type=DOI [3]: /lookup/external-ref?access_num=12374874&link_type=MED&atom=%2Fthoraxjnl%2F58%2F1%2F72.atom [4]: /lookup/external-ref?access_num=000178465100004&link_type=ISI |
