Lung Transplantation in Cystic Fibrosis and the Impact of Extracorporeal Circulation
| Autor: | Alberto Jauregui, Juan Solé, Antonio Moreno, Laura María Roa Romero, Maria Deu, Antonio Roman, Manuel Armengol |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Extracorporeal Circulation Adolescent Critical Care Cystic Fibrosis medicine.medical_treatment Partial Pressure Population Kaplan-Meier Estimate 030204 cardiovascular system & hematology Single Center Cystic fibrosis Gastroenterology 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine medicine Lung transplantation Humans education Child Cause of death Retrospective Studies Mechanical ventilation education.field_of_study business.industry Extracorporeal circulation Malnutrition Oxygen Inhalation Therapy General Medicine Carbon Dioxide Middle Aged medicine.disease Prognosis Combined Modality Therapy Transplantation Treatment Outcome 030228 respiratory system Female business Lung Transplantation |
| Zdroj: | Archivos de bronconeumologia. 54(6) |
| ISSN: | 2173-5751 |
| Popis: | Introduction Lung disease is the major cause of death among cystic fibrosis (CF) patients, affecting 80% of the population. The impact of extracorporeal circulation (ECC) during transplantation has not been fully clarified. This study aimed to evaluate the outcomes of lung transplantation for CF in a single center, and to assess the impact of ECC on survival. Methods We performed a retrospective observational study of all transplanted CF patients in a single center between 1992 and 2011. During this period, 64 lung transplantations for CF were performed. Results Five- and 10-year survival of transplanted patients was 56.7% and 41.3%, respectively. Pre-transplantation supplemental oxygen requirements and non-invasive mechanical ventilation (NIMV) do not seem to affect survival (P=.44 and P=.63, respectively). Five- and 10-year survival among patients who did not undergo ECC during transplantation was 75.69% and 49.06%, respectively, while in those did undergo ECC during the procedure, 5- and 10-year survival was 34.14% and 29.87%, respectively (P=.001). PaCO2 is an independent risk factor for the need for ECC. Conclusions The survival rates of CF patients undergoing lung transplantation in our hospital are similar to those described in international registries. Survival is lower among patients receiving ECC during the procedure. PaCO2 is a risk factor for the need for ECC during lung transplantation. |
| Databáze: | OpenAIRE |
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