Self-clearance of Pestivirus in a Pyrenean Chamois ( Rupicapra pyrenaica ) Population
| Autor: | Emmanuelle Gilot-Fromont, Brigitte Bonetti, Pierre Menaut, Sébastien Lambert, Yvette Game, Philippe Gibert, Gaël Reynaud, Kévin Foulché, Mathieu Garel |
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| Přispěvatelé: | Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Population Zoology Metapopulation Antibodies Viral Virus Border disease virus 03 medical and health sciences Rupicapra pyrenaica medicine Animals education Ecology Evolution Behavior and Systematics Epizootic ComputingMilieux_MISCELLANEOUS education.field_of_study Ecology biology Population size Pestivirus Pestivirus Infections Rupicapra biology.organism_classification medicine.disease 3. Good health 030104 developmental biology [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie France [SDE.BE]Environmental Sciences/Biodiversity and Ecology |
| Zdroj: | Journal of wildlife diseases Journal of wildlife diseases, 2018, 54 (2), pp.335-341. ⟨10.7589/2017-03-055⟩ Journal of wildlife diseases, Wildlife Disease Association, 2018, 54 (2), pp.335-341. ⟨10.7589/2017-03-055⟩ |
| ISSN: | 0090-3558 |
| DOI: | 10.7589/2017-03-055⟩ |
| Popis: | Understanding the dynamics of host-pathogen interaction is key to the management of epidemics. A pestivirus belonging to the border disease virus group 4 emerged around 2001 in Pyrenean chamois ( Rupicapra pyrenaica) in Spain and France. The virus had significant demographic impact in some populations, but it was less harmful and more endemic in other places. The determinants of these local variations are still unclear. Here, we documented empirical evidence of self-clearance of the virus in a chamois population in France. This population has regularly been counted, and chamois were trapped and harvested each year, providing unique demographic and epidemiologic surveys of the population since 1984 and 1994, respectively. The virus was detected using direct (PCR) and indirect (antibody) testing. We showed that virus transmission declined in 2011-12 and likely ceased in 2013, leading to a decline in antibody prevalence since 2014. Self-clearance may be due to limited exchanges with other populations, decrease in population size after an epizootic, and herd immunity. The age structure of captured animals shifted to younger age classes after virus self-clearance, suggesting a return to a colonizing population structure. The possible consequences of virus re-entry are discussed. This observation suggests that pestivirus dynamics occurs at the scale of the metapopulation of Pyrenean chamois. Local self-clearance and re-emergence may help explain the variation of virus dynamics at the local scale. |
| Databáze: | OpenAIRE |
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