Tolerance to analgesia and dependence liability by topical application of dihydroetorphine to hairless rats
| Autor: | Yasunori Morimoto, Masami Kawase, Setsuo Saito, Liang Fang, Satoshi Ohmori |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Dihydroetorphine Time Factors Substance-Related Disorders Injections Subcutaneous Narcotic Antagonists Pain relief Physical dependence Absorption (skin) Pharmacology Administration Cutaneous Rats Nude Pharmacokinetics Formaldehyde Conditioning Psychological Weight Loss medicine Animals Infusions Intravenous Inflammation Dose-Response Relationship Drug Morphine Naloxone business.industry Etorphine Drug Tolerance Rats Hairless Analgesics Opioid Anesthesia medicine.symptom business medicine.drug |
| Zdroj: | European Journal of Pharmacology. 423:157-166 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/s0014-2999(01)01098-6 |
| Popis: | The tolerance to analgesia and dependence liability of dihydroetorphine following topical application were investigated in hairless rats with and without formalin-induced inflammation. The analgesic effect of dihydroetorphine (s.c.) was 4600- to 7200-fold more potent than that of morphine. In non-inflamed rats, the analgesic effect of 24-h topical application of dihydroetorphine tape (35 microg) and 4-day repeated tape applications (20 microg/5 h/day) decreased with time after the start of application, even though the plasma dihydroetorphine concentrations did not decrease. In formalin-inflamed rats, however, the tolerance to analgesia diminished. Naloxone-precipitated weight loss was observed after 24-h infusion of dihydroetorphine but not after the tape application in non-inflamed rats. A significant rewarding effect was found in the non-inflamed rats conditioned by s.c. injection and tape application but not in the formalin-inflamed rats. These results indicate that topical application of dihydroetorphine has a tolerance and dependence liability when there is no pain, and therefore, it should be used only for pain relief. |
| Databáze: | OpenAIRE |
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