Alternative splicing variant of RHBDD2 is associated with cell stress response and breast cancer progression
| Autor: | Valeria Alejandra Ferretti, Ezequiel Lacunza, Sabina Palma, María Virginia Croce, Martín Enrique Rabassa, Romina Canzoneri, Martín Carlos Abba, Marina Teresita Isla Larrain, Agustina Gurruchaga |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Protein isoform Cancer Research Medicina Golgi Apparatus Breast Neoplasms Biology 03 medical and health sciences breast cancer 0302 clinical medicine Breast cancer Stress Physiological Cell Line Tumor subcellular localization Tumor Microenvironment medicine Humans Breast RNA Messenger Cell Proliferation protein isoform Oncogene Alternative splicing Genetic Variation Membrane Proteins Cancer Epithelial Cells General Medicine Cell cycle medicine.disease Neoplasm Proteins Gene Expression Regulation Neoplastic Alternative Splicing 030104 developmental biology Oncology Tumor progression RHBDD2 030220 oncology & carcinogenesis Cancer cell Disease Progression MCF-7 Cells Cancer research Female Neoplasm Recurrence Local |
| Zdroj: | SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP |
| ISSN: | 1791-2431 1021-335X |
| Popis: | RHBDD2 is an intramembrane pseudoprotease member of the Rhomboid superfamily. Our previous studies in breast and colorectal cancer indicate an association between RHBDD2 overexpression and advanced tumor stages. Two alternative transcriptional variants have been described for RHBDD2, which would be encoding for different RHBDD2 protein isoforms. The expression of these RHBDD2 variants/isoforms and its association with breast cancer was the focus of this study. First, expression of RHBDD2 splicing variants was evaluated in normal and breast tumor samples. RHBDD2 variant 2 overexpression was detected in tumors in respect to normal breast tissues at the mRNA and protein levels (P Facultad de Ciencias Médicas Centro de Investigaciones Inmunológicas Básicas y Aplicadas |
| Databáze: | OpenAIRE |
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