Increased serum ferritin is common in men with essential hypertension
| Autor: | Giuseppe Mancia, Anna Vergani, Viviana Mauri, Alessandra Salvioni, Raffaella Mariani, Alberto Piperno, P. Trombini, Valeria Pecci, Marisa Gelosa |
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| Přispěvatelé: | Piperno, A, Trombini, P, Gelosa, M, Mauri, V, Pecci, V, Vergani, A, Salvioni, A, Mariani, R, Mancia, G |
| Rok vydání: | 2002 |
| Předmět: |
metabolic disorder
Adult Liver Cirrhosis Male medicine.medical_specialty Iron Overload Physiology Arteriosclerosis medicine.medical_treatment insulin resistance syndrome Essential hypertension Risk Factors Internal medicine Internal Medicine medicine Humans Hepatic iron Risk factor Aged Sex Characteristics biology business.industry Insulin Case-control study essential hypertension serum ferritin Middle Aged medicine.disease Ferritin Endocrinology Case-Control Studies Increased serum ferritin Ferritins Hypertension biology.protein Female MED/09 - MEDICINA INTERNA Insulin Resistance Cardiology and Cardiovascular Medicine business Sex characteristics |
| Zdroj: | Journal of hypertension. 20(8) |
| ISSN: | 0263-6352 |
| Popis: | Objectives Insulin-resistance-associated hepatic iron overload syndrome (IRHIO) is characterized by high serum ferritin and presence of metabolic alterations that are part of insulin-resistance syndrome (IRS). Thus, clinical conditions characterized by a high prevalence of IRS may also be characterized by a high prevalence of IRHIO. Design and methods We studied 88 consecutive patients with essential hypertension, 62 patients with IRHIO and 102 healthy normotensive controls. Hemochromatosis, other conditions able to induce secondary iron overload or serum ferritin increase unrelated to body iron stores were excluded. Iron indices, metabolic profiles and hepatic tests in hypertensive with or without increased serum ferritin and in IRHIO with and without hypertension were studied. Metabolic variables, serum iron indices, liver function tests and hepatic ultrasound data were analysed. Data were compared by non-parametric tests. Results In men with hypertension, increased serum ferritin was more frequent than in controls (21 versus 0%, P = 0.001). Hypertensive men with increased serum ferritin had more frequent and pronounced metabolic alterations than those with normal serum ferritin, the metabolic abnormalities and serum ferritin being frequently positively correlated. In hypertensive men with increased serum ferritin, metabolic and iron data were similar to those of IRHIO patients with hypertension. Conclusions In males, hypertension is characterized by a higher prevalence of increased iron stores and metabolic abnormalities that are part of the IRHIO syndrome. This finding may have clinical implications due to the increased risk of IRHIO patients to develop hepatic cirrhosis and also for the role of iron in early atherogenesis. (C) 2002 Lippincott Williams Wilkins. |
| Databáze: | OpenAIRE |
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