POTENTIAL APPLICATIONS OF IMAGE-GUIDED RADIOTHERAPY FOR RADIATION DOSE ESCALATION IN PATIENTS WITH EARLY STAGE HIGH-RISK PROSTATE CANCER
| Autor: | Juan Godinez, Suresh Dutta, Satya Bose, Nam P. Nguyen, Rick Davis, Vincent Vinh-Hung, William Woods, Mark D’Andrea, Richard A Vo, Gabor Altdorfer, Thomas Sroka, Ulf Karlsson, Anand Desai, Alexander Chi |
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| Přispěvatelé: | Radiation Therapy, Translational Radiation Oncology and Physics, Faculty of Medicine and Pharmacy |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Cancer Research
medicine.medical_specialty medicine.medical_treatment Image-guided radiotherapy Review Article lcsh:RC254-282 Prostate cancer Quality of life Prostate high-risk medicine Stage (cooking) Survival rate Image-guided radiation therapy Gynecology business.industry Genitourinary system prostate cancer medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Radiation therapy Survival Rate medicine.anatomical_structure Oncology Keywords: Prostate cancer Hypofractionation Radiology business |
| Zdroj: | Frontiers in Oncology, Vol 5 (2015) Frontiers in Oncology |
| Popis: | Patients with early stage high-risk prostate cancer (prostate specific antigen > 20, Gleason score > 7) are at high risk of recurrence following prostate cancer irradiation. Radiation dose escalation to the prostate may improve biochemical-free survival for these patients. However, high rectal and bladder dose with conventional three-dimensional conformal radiotherapy may lead to excessive gastrointestinal and genitourinary toxicity. Image-guided radiotherapy (IGRT), by virtue of combining the steep dose gradient of intensity-modulated radiotherapy and daily pretreatment imaging, may allow for radiation dose escalation and decreased treatment morbidity. Reduced treatment time is feasible with hypo-fractionated IGRT and it may improve patient quality of life. |
| Databáze: | OpenAIRE |
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