Prevalence, Neonatal Characteristics, and First-Year Mortality of Down Syndrome: A National Study

Autor: Michel E. Weijerman, Jacobus P. van Wouwe, Antonie Vonk Noordegraaf, Reinoud J. B. J. Gemke, Chantal J.M. Broers, A. Marceline van Furth
Přispěvatelé: TNO Kwaliteit van Leven, Pediatric surgery, Obstetrics and gynaecology, EMGO - Quality of care, ICaR - Ischemia and repair
Rok vydání: 2008
Předmět:
Male
Questionnaires
Pediatrics
Down syndrome
newborn
Pregnancy
Surveys and Questionnaires
Prenatal Diagnosis
Infant Mortality
Prevalence
Birth Weight
Registries
gestational age
Child
Netherlands
statistical significance
register
adult
mother
article
Gestational age
trisomy 21
Parity
female
Breast Feeding
priority journal
Population Surveillance
breast milk
Apgar score
delivery
Live birth
Healthy Living
hospitalization
medicine.medical_specialty
Birth weight
live birth
Life Expectancy
Jeugd en Gezondheid
registration
Statistical significance
medicine
Humans
controlled study
human
newborn mortality
Biology
perinatal period
business.industry
Infant
Newborn
Infant
medicine.disease
major clinical study
mortality
Infant mortality
Pregnancy Complications
pediatric ward
Pediatrics
Perinatology and Child Health
Apgar Score
Healthy for Life
business
Breast feeding
Zdroj: Journal of Pediatrics, 1, 152, 15-19
Journal of Pediatrics, 152(1), 15-19. Mosby Inc.
Weijerman, M E, van Furth, A M, Vonk Noordegraaf, A, van Wouwe, J P, Broers, C J M & Gemke, R J B J 2008, ' Prevalence, neonatal characteristics, and first-year mortality of Down syndrome: a national study ', Journal of Pediatrics, vol. 152, no. 1, pp. 15-19 . https://doi.org/10.1016/j.jpeds.2007.09.045
ISSN: 0022-3476
Popis: Objective: To determine the prevalence, neonatal characteristics, and first-year mortality in Down syndrome (DS) among children in the Netherlands. Study design: The number of DS births registered by the Dutch Paediatric Surveillance Unit (DPSU) in 2003 was compared with total live births (reference population) and perinatal registrations. Results: The prevalence of DS was 16 per 10,000 live births. Compared with the reference population, the 182 children with trisomy 21 had a gestational age of 38 weeks versus 39.1 weeks (P < .001), a birth weight of 3119 g versus 3525 g in males (P < .001) and 2901 g versus 3389 g in females (P < .001), and mothers with a parity of ≥4.17% versus 5% (P < .001) and a mean age of 33.6 years versus 31 years (P < .001) and 33% (n = 54) ≥36 years). The mean age of DS diagnosis was 10.2 days in nonhospital deliveries and 1.8 days in hospital deliveries (P < .001). Children with DS were less often breast-fed (P < .05), and 86% (n = 156) were hospitalized after birth. Neonatal and infant mortality were higher in DS, 1.65% versus 0.36% (P < .02) and 4% versus 0.48% (P < 0.001), respectively. Conclusions: The prevalence of DS in the Netherlands exceeds previously reported levels and is influenced by the mother's age. Neonatal and infant DS mortality have declined, but still exceed those in the reference population. © 2008 Mosby, Inc. All rights reserved.
Databáze: OpenAIRE
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