Reduced Alcohol Use Is Sustained in Patients Provided Alcohol-Related Counseling During Direct-Acting Antiviral Therapy for Hepatitis C
| Autor: | Jia Yao, Rae Jean Proeschold-Bell, Andrew J. Muir, Donna Niedzwiecki, Yuval A. Patel, Elizabeth Goacher |
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| Rok vydání: | 2020 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhosis Alcohol Drinking Physiology media_common.quotation_subject Motivational interviewing Directive Counseling Alcohol Context (language use) Motivational Interviewing Antiviral Agents Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans media_common Cognitive Behavioral Therapy business.industry Alcohol Abstinence Gastroenterology Secondary data Hepatitis C Abstinence Hepatology Hepatitis C Chronic Middle Aged medicine.disease United States Alcoholism chemistry 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female business Risk Reduction Behavior |
| Zdroj: | Dig Dis Sci |
| ISSN: | 1573-2568 |
| Popis: | BACKGROUND: Patients with chronic hepatitis C and risky/harmful alcohol use experience poor outcomes. Granular data evaluating whether alcohol counseling during hepatitis C treatment impacts longitudinal alcohol consumption are lacking. AIMS: To evaluate whether provider-delivered counseling in the context of direct-acting antiviral hepatitis C treatment associates with decreased longitudinal alcohol consumption. METHODS: We performed secondary data analysis from the Hep ART study including adults with hepatitis C who underwent provider-delivered counseling during direct-acting antiviral treatment between October 2014 and September 2017. Demographics and disease characteristics were summarized. Alcohol consumption, abstinence, and heavy drinking were evaluated in periods before, during, and after direct-acting antiviral treatment. Multivariate regression analyses were performed to evaluate the association of alcohol consumption with each 12-week time period for all patients and a subsample with cirrhosis. RESULTS: One hundred twenty-three patients were included; 41 had cirrhosis. Most patients were male (74.0%) and Black (58.5%). Alcohol consumption improved during direct-acting antiviral treatment and was notably sustained (< 12 weeks before treatment 32.5 g/day; during treatment 20.0 g/day; and 12–24 weeks after treatment 23.7 g/day). Multivariable analyses showed significantly improved alcohol consumption metrics during and after antiviral treatment compared to < 12 weeks before treatment (during treatment 13.04 g/day less, p = 0.0001; > 24 weeks after treatment 15.29 g/day less, p = 0.0001). The subsample with cirrhosis showed similar results (during treatment 13.21 g/day less, p = 0.0001; > 24 weeks after treatment 7.69 g/day less, p = 0.0001). CONCLUSIONS: Patients with chronic HCV and risky/harmful alcohol use given provider-delivered alcohol-related counseling during HCV treatment sustain decreased alcohol consumption patterns during and after treatment. |
| Databáze: | OpenAIRE |
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