A model of immune regulation as a consequence of randomized lymphocyte division and death times
| Autor: | C. van Gend, Marian L. Turner, Edwin D. Hawkins, Mark R. Dowling, Philip D. Hodgkin |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Immunity Cellular Programmed cell death Time Factors Multidisciplinary Cell Death Cell division Cell Survival Lymphocyte Cellular Immunology Biological Sciences Biology Acquired immune system Models Biological Cell biology Mice Inbred C57BL Mice Tolerance induction Immune system medicine.anatomical_structure Immunity medicine Animals Lymphocytes Cell Division |
| Zdroj: | Proceedings of the National Academy of Sciences. 104:5032-5037 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.0700026104 |
| Popis: | The magnitude of an adaptive immune response is controlled by the interplay of lymphocyte quiescence, proliferation, and apoptosis. How lymphocytes integrate receptor-mediated signals influencing these cell fates is a fundamental question for understanding this complex system. We examined how lymphocytes interleave times to divide and die to develop a mathematical model of lymphocyte growth regulation. This model provides a powerful method for fitting and analyzing fluorescent division tracking data and reveals how summing receptor-mediated kinetic changes can modify the immune response progressively from rapid tolerance induction to strong immunity. An important consequence of our results is that intrinsic variability in otherwise identical cells, usually dismissed as noise, may have evolved to be an essential feature of immune regulation. |
| Databáze: | OpenAIRE |
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