The role of single nucleotide polymorphisms of miRNAs 100 and 146a as prognostic factors for prostate cancer
| Autor: | Miguel Srougi, Vanessa Guimarães, Juliana A. Camargo, Sabrina T. Reis, William C. Nahas, Renan Eboli Lopes, Nayara I. Viana, Alberto A. Antunes, Katia R. M. Leite, Gabriel Fernandes Dias Ferreira |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Prognostic factor Genotype Clinical Biochemistry Single-nucleotide polymorphism Polymorphism Single Nucleotide Pathology and Forensic Medicine Prostate cancer Prostate Internal medicine microRNA medicine Humans Base sequence Cancer death business.industry Incidence (epidemiology) Prostatic Neoplasms Prognosis medicine.disease MicroRNAs medicine.anatomical_structure business |
| Zdroj: | The International Journal of Biological Markers. 36:50-56 |
| ISSN: | 1724-6008 0393-6155 |
| DOI: | 10.1177/1724600821997461 |
| Popis: | Introduction: Prostate cancer has a high incidence in men and is the second cause of cancer death among americans male. microRNA (miR) is becoming a potential new prognostic factor for prostate cancer. Single nucleotide polymorphisms (SNPs) are common polymorphisms, characterized by a single exchange of nitrogen based in the DNA. This polymorphism is present in the miRs, altering their function. Objective: To evaluate the role of SNP rs1834306 of miR100 and rs2910164 of miR146a in the development and prognosis of prostate cancer. Methods: One hundred patients diagnosed with prostate cancer and 68 controls were selected. The identification of SNP was rated by quantitative polymerase chain reaction from blood samples, and the analysis was performed within the presence of SNP and the prognostic variables. Results: In the SNP rs1834306 (miR100), a smaller presence of the polymorphic homozygous genotype was identified in patients with PSA >10 ng/mL, ( P=0.03); when evaluating only the presence of the polymorphic allele G ( P=0.09) it was compared to the presence of the wild type allele A. Among the patients with prostate cancer, SNP rs2910164 (miR146A), the polymorphic allele was more frequent in patients with a Gleason score ⩾7 than in patients with a Gleason score Conclusions: SNP of miR146a acts as a poor prognostic factor (Gleason ⩾7), and the SNP of miR100 is linked to better prognostic data (PSA |
| Databáze: | OpenAIRE |
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