Pre-transplant ALBI Grade 3 Is Associated with Increased Mortality After Liver Transplantation
| Autor: | Thais Ortiz Hammes, Ariane Nádia Backes, Léa Teresinha Guerra, Nicole Bernardi, Carolina Prediger, Tomaz J. M. Grezzana-Filho, Alexandre de Araujo, Mário Reis Álvares-da-Silva, Cleber Rosito Pinto Kruel, João E Prediger, Marcelo A Pinto, Ian Leipnitz, Aljamir Duarte Chedid, Marcio F. Chedid |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Carcinoma Hepatocellular Time Factors Physiology Hepatic resection medicine.medical_treatment Clinical Decision-Making Serum Albumin Human Liver transplantation Gastroenterology Risk Assessment Decision Support Techniques 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors Internal medicine medicine Clinical endpoint Humans Retrospective Studies business.industry Liver Neoplasms Bilirubin Hepatology Middle Aged medicine.disease Liver Transplantation Treatment Outcome 030220 oncology & carcinogenesis Hepatocellular carcinoma 030211 gastroenterology & hepatology Female Neoplasm Grading Low serum albumin business Elevated body mass index Biomarkers |
| Zdroj: | Digestive diseases and sciences. 64(6) |
| ISSN: | 1573-2568 |
| Popis: | Although MELD score is a reliable tool for estimating mortality in the waiting list, criteria for preoperative prediction of survival after liver transplantation (LT) are lacking. ALBI score was validated as a prognostic marker for hepatocellular carcinoma patients undergoing transarterial chemoembolization, hepatic resection, and sorafenib treatment but not for LT outcomes yet. This study aimed to evaluate ALBI score as a prognostic factor in LT. This is a single-center analysis of patients undergoing LT between October 2001 and June 2017. Primary endpoint was overall post-LT mortality. Secondary endpoint was 90-day mortality. Of all 301 patients included in this study, 185 (61.5%) were males. The median age was 54.1 ± 11.3 years. Univariate and multivariate analysis revealed that ALBI grade 3 (HR 1.836, 95% CI 1.154–2.921, p = 0.010), low serum albumin (HR 0.628, 95% CI 0.441–0.893, p = 0.010), black race (HR 2.431, 95% CI 1.160–5.092, p = 0.019), and elevated body mass index (HR 1.061, 95% CI 1.022–1.102, p = 0.002) all were associated with decreased overall survival following LT. Patients with both ALBI grade 3 (n = 25) and calculated MELD score ≥ 25 had the lowest overall survival (p |
| Databáze: | OpenAIRE |
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