Systematic screening of chromosome 18 for loss of heterozygosity in esophageal squamous cell carcinoma
| Autor: | Louis Y. Korman, Robert G. Wadleigh, Timothy O. Lipman, Takeo Yoshikawa, Nirmal Sani, Robert H. Patterson, Kannan V. Balan, Aparna Sharma, Sevilla D. Detera-Wadleigh, Jayaprakash D. Karkera |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Genetics
Cancer Research Tumor suppressor gene Esophageal Neoplasms Esophageal disease Chromosomal fragile site Loss of Heterozygosity Biology Esophageal cancer medicine.disease medicine.disease_cause Loss of heterozygosity Epidermoid carcinoma Chromosome 18 medicine Cancer research Carcinoma Squamous Cell Humans Genes Tumor Suppressor Carcinogenesis Chromosomes Human Pair 18 Molecular Biology Alleles |
| Zdroj: | Cancer genetics and cytogenetics. 111(1) |
| ISSN: | 0165-4608 |
| Popis: | Esophageal cancer ranks among the 10 most common cancers in the world, and is almost uniformly fatal. The genetic events leading to the development of esophageal carcinoma are not well established. To identify genomic regions involved in esophageal carcinogenesis, we performed a systematic screening for loss of heterozygosity (LOH) in 24 samples of squamous cell carcinomas, initially focusing the analysis on chromosome 18. Thirteen short tandem repeat markers spanning 18p and 18q were used. We found a broad peak of LOH spanning 18p11.2 and 18q21.1 with the most frequent LOH (72%) at D18S978 on 18q12.2, which coincides with a known fragile site FRA18A. This region is 4 cM proximal to known tumor suppressor genes and therefore suggests the possible existence of a yet undiscovered tumor suppressor gene. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect