Prions, prionoids and pathogenic proteins in Alzheimer disease
| Autor: | Karen H. Ashe, Adriano Aguzzi |
|---|---|
| Přispěvatelé: | University of Zurich, Ashe, Karen H |
| Rok vydání: | 2012 |
| Předmět: |
1303 Biochemistry
prionoids Amyloid β Prions animal diseases Mini Review 10208 Institute of Neuropathology 2804 Cellular and Molecular Neuroscience 610 Medicine & health Disease Biology amyloid-β Biochemistry 1307 Cell Biology Cellular and Molecular Neuroscience Prion infectivity Alzheimer Disease medicine Dementia Animals Humans tau Prion protein pathogenic proteins PrP Amyloid beta-Peptides Brain 2725 Infectious Diseases Cell Biology medicine.disease Virology Neurological effects 3. Good health nervous system diseases Infectious Diseases Toxicity 570 Life sciences biology Alzheimer's disease Alzheimer’s disease |
| Zdroj: | Prion |
| ISSN: | 1933-690X |
| Popis: | Like patients with prion disease, Alzheimer patients suffer from a fatal, progressive form of dementia. There is growing evidence that amyloid-β (Aβ) aggregates may be transmissible similar to prions, at least under extreme experimental conditions. However, unlike mice infected with prion protein (PrP) prions, those inoculated with Aβ do not die. The transmission of Aβ and PrP thus differs conspicuously in the neurological effects they induce in their hosts, the difference being no less than a matter of life and death. Far from being a mere academic nuance, this distinction between Aβ and PrP begs the crucial questions of what, exactly, controls prion toxicity and how prion toxicity relates to prion infectivity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|