Herpes simplex encephalitis: A serological follow-up study
| Autor: | Anders Carlstrom, Pekka Halonen, Kirsti Kalimo, Marianne Forsgren, Birgit Sköldenberg |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Immunoglobulin A viruses Radioimmunoassay Immunoglobulins medicine.disease_cause Immunoglobulin G Virus Serology Virus antigen Meningoencephalitis medicine Humans biology business.industry Herpes Simplex General Medicine Middle Aged medicine.disease Virology Herpes simplex virus Immunoglobulin M Neurology Immunology biology.protein Female Neurology (clinical) business Encephalitis Follow-Up Studies |
| Zdroj: | Acta Neurologica Scandinavica. 63:273-285 |
| ISSN: | 1600-0404 0001-6314 |
| Popis: | A solid-phase radioimmunoassay method was used for the detection of herpes simplex virus (HSV) immunoglobulin M (IgM), IgA, and IgG antibodies within the central nervous system in 11 patients with acute HSV encephalitis. Serial cerebrospinal fluid (CSF) and serum specimens were sampled during the observation periods, extending up to 43 months after onset. The clinical diagnosis of HSV encephalitis was confirmed demonstrating virus or virus antigen in the central nervous system in four patients and with significant HSV antibodies in CSF in all the patients. In acute stage CSF HSV antibodies of a significant level were demonstrated in one of four samples taken on days 3--4 after onset, and in samples taken on days 6--8 in five of nine patients. CSF HSV antibodies of a significant and high level were detected in all samples taken from day 10 after onset. Intrathecal production of HSV IgM and IgA antibodies lasted from 7 weeks to 43 months during the observation periods. All patients had persistent intrathecal production of HSV IgG antibodies as well as of oligoclonal IgG during the total observation periods up to 43 months. |
| Databáze: | OpenAIRE |
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