Expression of α-Defensins, CD20+ B-lymphocytes, and Intraepithelial CD3+ T-lymphocytes in the Intestinal Mucosa of Patients with Liver Cirrhosis: Emerging Mediators of Intestinal Barrier Function
| Autor: | Michalis Petropoulos, Iris Spiliopoulou, Georgios I. Theocharis, Vasileios Theopistos, Georgia Diamantopoulou, Konstantinos Thomopoulos, Eleni C. Papaioannou, Stelios F Assimakopoulos, Georgios I. Tsiaoussis, Eleni Kourea, Zoi Lygerou |
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| Rok vydání: | 2018 |
| Předmět: |
Liver Cirrhosis
Male 0301 basic medicine Paneth Cells alpha-Defensins medicine.medical_specialty Cirrhosis Lymphoid Tissue Physiology Gut-associated lymphoid tissue Group A Gastroenterology 03 medical and health sciences Intestinal mucosa Internal medicine medicine Humans Lymphocytes Prospective Studies Immunity Mucosal Barrier function Lamina propria business.industry Middle Aged Hepatology medicine.disease Endotoxins 030104 developmental biology Lymphatic system medicine.anatomical_structure Female business |
| Zdroj: | Digestive Diseases and Sciences. 63:2582-2592 |
| ISSN: | 1573-2568 0163-2116 |
| Popis: | The present study investigates the role of innate and adaptive immune system of intestinal mucosal barrier function in cirrhosis. Forty patients with decompensated (n = 40, group A), 27 with compensated cirrhosis (n = 27, group B), and 27 controls (n = 27, group C) were subjected to duodenal biopsy. Expression of α-defensins 5 and 6 at the intestinal crypts was evaluated by immunohistochemistry and immunofluorescence. Serum endotoxin, intestinal T-intraepithelial, and lamina propria B-lymphocytes were quantified. Cirrhotic patients presented higher endotoxin concentrations (p |
| Databáze: | OpenAIRE |
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