Comparative activity of memory-modulating neuropeptides before and after electric shock in white rats
| Autor: | V. D. Bakharev, O. A. Kaurov, V. I. Medvedev |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Vasopressin
Enkephalin Arginine Neuropeptide Amnesia Oxytocin Adrenocorticotropic Hormone Memory medicine Avoidance Learning Animals Humans General Neuroscience MSH Release-Inhibiting Hormone Peptide Fragments Rats Arginine Vasopressin Future study medicine.symptom Psychology Peptides Neuroscience hormones hormone substitutes and hormone antagonists medicine.drug Enkephalin Leucine |
| Zdroj: | Neuroscience and behavioral physiology. 15(3) |
| ISSN: | 0097-0549 |
| Popis: | Neuropeptides are shown to exert a powerful influence on mnestic processes. They actively eliminate phenomena of electric-shock amnesia, the strongest agent here being arginine vasopressin, while derivatives of oxytocin, enkephalin, and melanostatin are active to a lesser degree. The selective effect on primary learning (ACTH4-7 and Leu-enkephalin) and on the consolidation and restoration of memory (vasopressin and oxytocin), and the presence of only antiamnestic properties (analog of the melanocyte-inhibiting factor) - all this suggests different mechanisms of action of these agents. Memory modulators act more strongly upon activated systems that are already prepared to receive the signal. A promising object for future study as a therapeutic antiamnestic factor is the long-term memory modulator arginine vasopressin. |
| Databáze: | OpenAIRE |
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