Oxytetracycline recovery from aqueous media using computationally designed molecularly imprinted polymers
| Autor: | Rosa A. Lorenzo, Angel Concheiro, Antonia M. Carro, Carmen Alvarez-Lorenzo, Rosalía Rodríguez-Dorado, Kal Karim, Iva Chianella, Sergey A. Piletsky |
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| Rok vydání: | 2016 |
| Předmět: |
Alkanesulfonates
Models Molecular Oxytetracycline 02 engineering and technology Methacrylate 01 natural sciences Biochemistry Polymerization Water Purification Analytical Chemistry Molecular Imprinting Adsorption Rebinding isothern Solid phase extraction Groundwater Molecularly imprinted polymer chemistry.chemical_classification Solid-phase extraction Acrylamides Computational design Chromatography Chemistry Solid Phase Extraction 010401 analytical chemistry Extraction (chemistry) Polymer 021001 nanoscience & nanotechnology Anti-Bacterial Agents 0104 chemical sciences Ionic strength Groundwater remediation Methacrylates 0210 nano-technology Molecular imprinting Water Pollutants Chemical |
| Zdroj: | Analytical and Bioanalytical Chemistry. 408:6845-6856 |
| ISSN: | 1618-2650 1618-2642 |
| Popis: | Polymers for recovery/removal of the antimicrobial agent oxytetracycline (OTC) from aqueous media were developed with use of computational design and molecular imprinting. 2-Hydroxyethyl methacrylate, 2-acrylamide-2-methylpropane sulfonic acid (AMPS), and mixtures of the two were chosen according to their predicted affinity for OTC and evaluated as functional monomers in molecularly imprinted polymers and nonimprinted polymers. Two levels of AMPS were tested. After bulk polymerization, the polymers were crushed into particles (200-1000 μm). Pressurized liquid extraction was implemented for template removal with a low amount of methanol (less than 20 mL in each extraction) and a few extractions (12-18 for each polymer) in a short period (20 min per extraction). Particle size distribution, microporous structure, and capacity to rebind OTC from aqueous media were evaluated. Adsorption isotherms obtained from OTC solutions (30-110 mg L(-1)) revealed that the polymers prepared with AMPS had the highest affinity for OTC. The uptake capacity depended on the ionic strength as follows: purified watersaline solution (0.9 % NaCl)seawater (3.5 % NaCl). Polymer particles containing AMPS as a functional monomer showed a remarkable ability to clean water contaminated with OTC. The usefulness of the stationary phase developed for molecularly imprinted solid-phase extraction was also demonstrated. Graphical Abstract Selection of functional monomers by molecular modeling renders polymer networks suitable for removal of pollutants from contaminated aqueous environments, under either dynamic or static conditions. |
| Databáze: | OpenAIRE |
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