Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana moens ex trimen

Autor:	Ki-Hyung Suh, Belinda J. Lee, Mi-Hee Kim, Sung-Eun Lee, Sun Chul Huh, Won-Sik Choi, Byeoung-Soo Park, Dae Young Kim, Tae-Lin Huh, Eun Ju Park, Young Jae Choi, Jang-Eok Kim, Sung Min Kim, Philip J. Rosenthal
Rok vydání:	2002
Předmět:	Models Molecular Plasmodium Erythrocytes Magnetic Resonance Spectroscopy Stereochemistry Cinchona Alkaloids Cinchona ledgeriana Clinical Biochemistry Drug Resistance Molecular Conformation Pharmaceutical Science Biochemistry Chemical synthesis Antimalarials Structure-Activity Relationship chemistry.chemical_compound Bromide Drug Discovery Animals Humans Structure–activity relationship Organic chemistry Molecular Biology biology Bicyclic molecule Alkaloid Organic Chemistry Quinoline Chloroquine Plasmodium falciparum biology.organism_classification chemistry Drug Design Quinolines Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 12:1351-1355
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(02)00173-7
Popis:	In the course of attempts to develop antimalarial drugs, we have designed and synthesized a series of quinoline alkaloide derivatives. Three of them, N-(4-methoxy-3,5-di-tert-butylbenzyl)cinchonidinium bromide (OSL-5), O-benzyl-N-(3,5-di-tert-butyl-4-methoxybenzyl)cinchonidinium bromide (OSL-7), and N-(3,5-di-tert-butyl-4-methoxybenzyl)quininium bromide (OSL-14) show potent activity against Plasmodium falciparum.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12094fb5cb3e5034acd6264da676717b https://doi.org/10.1016/s0960-894x(02)00173-7 Zobrazit plný text záznamu Full Text from ScienceDirect