Comparable Enhanced Prothrombogenesis in Simple Central Obesity and Metabolic Syndrome
| Autor: | Hapizah Md Nawawi, Zaliha Ismail, Hanis Saimin, Noor Shafina Mohd Nor, Nadzimah Mohd Nasir, Suraya Abdul Razak, Thuhairah Hasrah Abdul Rahman |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty lcsh:Internal medicine Article Subject Endocrinology Diabetes and Metabolism medicine.medical_treatment Blood sugar Blood lipids 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Tissue plasminogen activator 03 medical and health sciences 0302 clinical medicine Internal medicine Blood plasma Fibrinolysis Plasminogen Activator Inhibitor 1 medicine Humans lcsh:RC31-1245 Aged Metabolic Syndrome business.industry Middle Aged medicine.disease Endocrinology Blood pressure Cross-Sectional Studies Obesity Abdominal Tissue Plasminogen Activator Female Metabolic syndrome Waist Circumference business Plasminogen activator Biomarkers medicine.drug Research Article |
| Zdroj: | Journal of Obesity Journal of Obesity, Vol 2018 (2018) |
| ISSN: | 2090-0716 |
| Popis: | Objective. There is limited data comparing prothrombogenic or fibrinolysis biomarkers (tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1)) simultaneously in subjects with Metabolic Syndrome (MS), simple central obesity without MS (COB) and normal controls (NC). We investigated the concentrations of fibrinolysis biomarkers in subjects with MS, COB and NC.Methods. A cross-sectional study involving 503 drug naive subjects (163 males, aged 30–65 years old (mean age ± SD = 47.4 ± 8.3 years)) divided into MS, COB and NC groups. COB was defined as central obesity (waist circumference (WC) males ≥90 cm, females ≥80 cm) in the absence of MS according to the International Diabetes Federation 2006. Fasting blood levels of tPA and PAI-1were analyzed.Results. MS and COB had significantly higher concentration of all biomarkers compared to NC. The MS group had significantly higher concentration of tPA and PAI-1 compared to COB. WC and HDL-c had significant correlation with all biomarkers (tPAp<0.001, PAI-1p<0.001). Fasting plasma glucose and diastolic blood pressure were independent predictors after correcting for confounding factors.Conclusion. Central obesity with or without MS both demonstrated enhanced prothrombogenesis. This suggests that simple obesity possibly increases the risk of coronary artery disease in part, via increased susceptibility to thrombogenesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text