Systematic review and meta-analysis of vagus nerve stimulation in the treatment of depression: variable results based on study designs
| Autor: | Jose Luis R. Martin, Eva Martin-Sanchez |
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| Rok vydání: | 2011 |
| Předmět: |
Research design
Depressive Disorder/*Therapy medicine.medical_specialty Vagus Nerve Stimulation medicine.medical_treatment Research Design Placebo 01 natural sciences Severity of Illness Index 010104 statistics & probability Randomized Controlled Trials As Topic 0504 sociology Rating scale Internal medicine Severity of illness medicine Humans 0101 mathematics Depression (differential diagnoses) Psiquiatría Randomized Controlled Trials as Topic Depressive Disorder Clinical study design 05 social sciences 050401 social sciences methods Psychiatry and Mental health Treatment Outcome Meta-analysis Physical therapy Psychology Vagus nerve stimulation |
| Zdroj: | European psychiatry : the journal of the Association of European Psychiatrists. 27(3) |
| ISSN: | 1778-3585 0924-9338 |
| Popis: | Purpose:To determine the efficacy of vagus nerve stimulation (VNS) for treatment of depression.Methods:We conducted a systematic review and meta-analysis of analytical studies. Efficacy was evaluated according to severity of illness and percentage of responders.Results:We identified 687 references. Of these, 14 met the selection criteria and were included in the review. The meta-analysis of efficacy for uncontrolled studies showed a significant reduction in scores at the Hamilton Depression Rating Scale endpoint, and the percentage of responders was 31.8% ([23.2% to 41.8%], PP = 0.25). To study the cause of this heterogeneity, a meta-regression was performed. The adjusted coefficient of determination (R2Adj) was 0.84, which implies that an 84% variation in effect size across the studies was explained by baseline severity of depression (PConclusion:Currently, insufficient data are available to describe VNS as effective in the treatment of depression. In addition, it cannot be ruled out that the positive results observed in the uncontrolled studies might have been mainly due to a placebo effect. |
| Databáze: | OpenAIRE |
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