Natural Function and Structural Modification of Climacostol, a Ciliate Secondary Metabolite
Autor: | Claudio Ortenzi, Cristina Cimarelli, Davide Cervia, Enrico Marcantoni, Elisabetta Catalani, Federico Buonanno |
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Rok vydání: | 2020 |
Předmět: |
0106 biological sciences
Microbiology (medical) natural products Climacostomum virens Settore BIO/05 - Zoologia Ciliates Natural products Predator Prey interactions Resorcinolic lipids Secondary metabolites Review Computational biology Secondary metabolite 01 natural sciences Microbiology 03 medical and health sciences Virology medicine lcsh:QH301-705.5 030304 developmental biology Ciliate 0303 health sciences resorcinolic lipids Ciliated protozoan biology secondary metabolites Chemistry 010604 marine biology & hydrobiology predator–prey interactions Settore CHIM/06 - Chimica Organica Antimicrobial biology.organism_classification Climacostol lcsh:Biology (General) ciliates Chemical defense Function (biology) medicine.drug |
Zdroj: | Microorganisms, Vol 8, Iss 809, p 809 (2020) Microorganisms |
ISSN: | 2076-2607 |
Popis: | The review highlights the main results of two decades of research on climacostol (5-[(2Z)-non-2-en-1-yl]benzene-1,3-diol), the resorcinolic lipid produced and used by the ciliated protozoan Climacostomum virens for chemical defense against a wide range of predators, and to assist its carnivorous feeding. After the first studies on the physiological function of climacostol, the compound and some analogues were chemically synthesized, thus allowing us to explore both its effect on different prokaryotic and eukaryotic biological systems, and the role of its relevant structural traits. In particular, the results obtained in the last 10 years indicate climacostol is an effective antimicrobial and anticancer agent, bringing new clues to the attempt to design and synthesize additional novel analogues that can increase or optimize its pharmacological properties. |
Databáze: | OpenAIRE |
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