Adiponutrin: A New Gene Regulated by Energy Balance in Human Adipose Tissue
| Autor: | Bernard Hainque, Arnaud Basdevant, Marthe Moldes, Yong-ming Liu, Jean-Philippe Bastard, Karine Clément, Eric Bruckert, Dominique Langin, Jacques Pairault, Nathalie Viguerie |
|---|---|
| Přispěvatelé: | Physiologie et physiopathologie (PP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Institut Louis Bugnard, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse) |
| Rok vydání: | 2004 |
| Předmět: |
Adult
medicine.medical_specialty [SDV]Life Sciences [q-bio] Endocrinology Diabetes and Metabolism Clinical Biochemistry Adipose tissue Biology Biochemistry chemistry.chemical_compound Endocrinology Internal medicine Adipocyte Gene expression medicine Humans Adiponutrin Adiponutrin: adipose tissue human Obesity RNA Messenger education Gene Messenger RNA education.field_of_study Adiponectin Reverse Transcriptase Polymerase Chain Reaction Leptin Biochemistry (medical) Membrane Proteins energy balance Adipose Tissue Gene Expression Regulation chemistry Female Energy Intake Energy Metabolism |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism Journal of Clinical Endocrinology and Metabolism, 2004, 89 (6), pp.2684-2689. ⟨10.1210/jc.2003-031978⟩ |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2003-031978 |
| Popis: | International audience; Adiponutrin is a newly identified nonsecreted adipocyte protein regulated by changes in energy balance in rodents. We documented the influence of energy balance modification on adiponutrin gene expression in humans. We investigated the mRNA expression in sc adipose tissue of nonobese women and in obese women during 2-d very low-calorie diet (VLCD) and subsequent refeeding as well as before and after a VLCD of 3 wk (21-d VLCD). The adiponutrin mRNA levels of the nonobese and obese women were not different (P > 0.05). Two-day VLCD reduced the average level of adiponutrin mRNA expression by 36% (P = 0.0016), whereas refeeding elevated the mRNA level by 31% (P = 0.004). The 3-wk VLCD caused a dramatic 58% fall of the adiponutrin mRNA expression level (P = 0.001). The mRNA level was negatively correlated with fasting glucose (Rho = -0.62; P < 0.0001), and subjects with high adiponutrin mRNA level had an increased insulin sensitivity. Compared with other adipocyte proteins such as leptin and adiponectin, adiponutrin mRNA did not show correlation with either adiposity indexes or with leptin or adiponectin mRNAs. These results indicate that adiponutrin gene expression in humans is highly regulated by changes in energy balance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|