Unraveling the Possible Routes of SARS-COV-2 Invasion into the Central Nervous System
| Autor: | Aristidis Tsatsakis, Maria Lima, Ioannis Liampas, Anastasios Papadimitriou, Alexios-Fotios A. Mentis, Vasileios Siokas, Stavros J. Baloyannis, Dimitrios P. Bogdanos, Panayiotis Mitsias, Zisis Tsouris, Efthimios Dardiotis, Athina-Maria Aloizou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Neurology Neurovirulence Coronavirus disease 2019 (COVID-19) Reflections from the COVID Pandemic (A Iranzo and M Rosenfeld Section Editors) CNS penetration viruses Neurotropism Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Central nervous system SARS-2 medicine.disease_cause Virus Neuroinvasion Cns penetration 03 medical and health sciences 0302 clinical medicine Medicine skin and connective tissue diseases Coronavirus Pandemic Coronaviruses (CoVs) SARS-CoV-2 business.industry COVID-19 virus diseases respiratory system respiratory tract diseases medicine.anatomical_structure 030220 oncology & carcinogenesis Neurological manifestations Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Current Treatment Options in Neurology |
| ISSN: | 1092-8480 |
| Popis: | Purpose of Review To describe the possible neuroinvasion pathways of Severe Acute Respiratory Syndrome-related Coronavirus-2 (SARS-CoV-2), the virus responsible for the Coronavirus disease-19 (Covid-19) pandemic. Recent Findings We present data regarding the family of Coronaviruses (CoVs) and the central nervous system (CNS), and describe parallels between SARS-CoV-2 and other members of the family, which have been investigated in more depth and combine these findings with the recent advancements regarding SARS-CoV-2. Summary SARS-CoV-2 like other CoVs is neuroinvasive, neurotropic and neurovirulent. Two main pathways of CNS penetration seem to be the strongest candidates, the hematogenous and the neuronal. Τhe olfactory route in particular appears to play a significant role in neuroinvasion of coronaviruses and SARS-CoV-2, as well. However, existing data suggest that other routes, involving the nasal epithelium in general, lymphatic tissue and the CSF may also play roles in SARS-CoV-2 invasion into the CNS. |
| Databáze: | OpenAIRE |
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