Exportin-T: A Novel Prognostic Predictor and Potential Therapeutic Target for Neuroblastoma
| Autor: | Zhixiang Wu, Yeming Wu, Lijia Pan, Jian-Lei Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research Nucleocytoplasmic Transport Proteins Adolescent Exportin-T Biology EXPORTIN-T Neuroblastoma Young Adult Cell Movement medicine Biomarkers Tumor Humans Molecular Targeted Therapy RNA Small Interfering Child RC254-282 Cell Proliferation Neoplasm Staging Proportional Hazards Models Gene Expression Profiling therapeutic target Disease Management Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Prognosis Immunohistochemistry Cell biology Gene Expression Regulation Neoplastic Oncology ROC Curve Nucleocytoplasmic Transport Gene Knockdown Techniques Original Article Female RNA Interference Disease Susceptibility prognostic marker |
| Zdroj: | Technology in Cancer Research & Treatment, Vol 20 (2021) Technology in Cancer Research & Treatment |
| ISSN: | 1533-0338 |
| Popis: | Exportins as the key mediators of nucleocytoplasmic transport have been identified as the controllers of the passage of numerous types of crucial cancer-related proteins. Targeting exportins in cancer cells might represent an emerging strategy in cancer intervention with the potential to affect clinical outcomes. Here, we focused on the prognostic and therapeutic values of Exportin-T (XPOT) in neuroblastoma. The correlation between the expression and prognostic values of XPOT in patients with neuroblastoma was investigated based on both published transcriptome data and our clinical data. Then, decision curve analysis (DCA) was implemented to identify a XPOT risk prediction model. In addition, RNA inference was performed to silence the expression of XPOT to further investigate the specific roles of XPOT in the progression of neuroblastoma in vitro. Overexpression of XPOT mRNA was associated with poor clinical characteristics, such as age at diagnosis more than 18 months, amplification of MYCN, and advanced International Neuroblastoma Staging System (INSS) stage, and XPOT expression was identified as an independent poor prognosis factor for neuroblastoma using Cox proportional hazards model ( P |
| Databáze: | OpenAIRE |
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