Conversion of adamsite (phenarsarzin chloride) by fungal manganese peroxidase
| Autor: | O. Tsivunchyk, Klaus Steinbach, Martin Hofrichter, R. Haas, Katrin Scheibner, Eberhard von Löw |
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| Rok vydání: | 2003 |
| Předmět: |
inorganic chemicals
Sodium Metabolite Inorganic chemistry chemistry.chemical_element Applied Microbiology and Biotechnology Chloride Arsenicals chemistry.chemical_compound Manganese peroxidase medicine Chemical Warfare Agents Biotransformation Manganese Cell-Free System biology Adamsite General Medicine Glutathione Malonates Malonate Peroxidases chemistry biology.protein Oxidation-Reduction Biotechnology Nuclear chemistry Peroxidase medicine.drug |
| Zdroj: | Applied Microbiology and Biotechnology. 63:564-566 |
| ISSN: | 1432-0614 0175-7598 |
| DOI: | 10.1007/s00253-003-1453-x |
| Popis: | Fungal manganese peroxidase was found to convert the persistent chemical warfare agent adamsite (phenarsarzin chloride) in a cell-free reaction mixture containing sodium malonate, Mn(2+) ions, and reduced glutathione. The organo-arsenical compound disappeared completely within 48 h accompanied by the formation of a more polar metabolite with a clearly modified UV spectrum. Thus, As(III) in the adamsite molecule was oxidized by manganese peroxidase to As(V) which added dioxygen and released chloride. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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