Uveal Melanoma Cell Seeding after Transretinal Tumor Biopsy?
| Autor: | Ahmed M. Hishmi, Monika Ortmann, Ludwig M. Heindl, Konrad R. Koch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pars plana medicine.medical_specialty Pathology medicine.medical_treatment Posterior pole Lesion 03 medical and health sciences 0302 clinical medicine Biopsy Medicine Case Series and Brief Reports General Nursing medicine.diagnostic_test business.industry Melanoma Enucleation of the eye medicine.disease Primary tumor eye diseases 030104 developmental biology medicine.anatomical_structure 030221 ophthalmology & optometry Histopathology sense organs medicine.symptom business |
| Popis: | Background/Aims: To report a case and the histopathology of uveal melanoma cell seeding following transretinal tumor biopsy for a suspected uveal lesion. Methods: Interventional case report. Results: A 66-year-old male presented with a pigmented perilimbal episcleral lesion overlying an intraocular mass at the pars plana, 3.5 years after transretinal biopsy and ruthenium plaque brachytherapy for a choroidal melanoma at the posterior pole. The patient underwent enucleation of the eye. Histopathology confirmed a recurrence of uveal melanoma with intra- and extrascleral tumor portions. Serial sections revealed the posterior border of this newfound pars plana melanoma separated from the radiation scar by a viable and tumor-free choroidal area, thus failing to establish a continuity between secondary and primary tumor. Conclusion: Transretinal tumor biopsy is of high diagnostic and prognostic value in the management of uveal lesions, but also bears the potential risk for tumor cell seeding. |
| Databáze: | OpenAIRE |
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