Proteinuria in metastatic pheochromocytoma is associated with an increased risk of Acute Respiratory Distress Syndrome, spontaneously or after therapy with 131I-meta-iodobenzylguanidine (131I-MIBG)
| Autor: | Miguel Hernandez Pampaloni, Katherine K. Matthay, Robert E. Goldsby, P. A. Fitzgerald, Fabienne Hollinger, Randy Hawkins, Lloyd E. Damon, A Porzig, Steven G. DuBois |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Compassionate Use Trials Male medicine.medical_specialty ARDS Urinalysis Adolescent Endocrinology Diabetes and Metabolism Clinical Biochemistry Adrenal Gland Neoplasms Antineoplastic Agents Pheochromocytoma Biochemistry chemistry.chemical_compound Young Adult Endocrinology Fatal Outcome Risk Factors Internal medicine medicine Humans Prospective cohort study Child Radionuclide Imaging Metanephrine Aged Retrospective Studies Respiratory Distress Syndrome Proteinuria medicine.diagnostic_test business.industry Biochemistry (medical) Retrospective cohort study General Medicine Metanephrines Middle Aged medicine.disease 3-Iodobenzylguanidine chemistry Female Radiography Thoracic medicine.symptom business |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 44(7) |
| ISSN: | 1439-4286 |
| Popis: | Acute Respiratory Distress Syndrome (ARDS) has been reported rarely in pheochromocytoma, occurring spontaneously or after therapy with 131I-meta-iodobenzylguanidine (131I-MIBG). Our objective was to determine whether proteinuria is associated with an increased risk of ARDS. This was a retrospective analysis of a prospective cohort study of 64 patients with metastatic pheochromocytoma or paraganglioma treated with 131I-MIBG on institutional protocols. Proteinuria was defined as at least one urinalysis positive for at least trace protein within 1 month prior to 131I-MIBG or within 1 month prior to spontaneous ARDS. Proportions were compared using Fisher's exact test. Urinalyses within the defined time period were available for 48 patients, 8 of whom had proteinuria. Of the 8 patients with proteinuria, 5 developed ARDS: 3 within 10 days following 131I-MIBG, two 6 months following 131I-MIBG. Both patients who developed ARDS 6 months after 131I-MIBG had proteinuria within 1 month before apparently spontaneous ARDS. None of the 40 patients whose urinalyses were all negative for protein developed ARDS. None of the 16 patients with missing urinalyses developed ARDS. Patients with antecedent proteinuria were more likely to develop ARDS than those without proteinuria (63% vs. 0%; p |
| Databáze: | OpenAIRE |
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