Cancer after cholecystectomy: record-linkage cohort study
| Autor: | Valerie Seagroatt, Julie Abisgold, Michael J Goldacre, David Yeates |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Colorectal cancer Epidemiology medicine.medical_treatment pancreatic cancer cholecystectomy Rate ratio Gastroenterology Medical Records liver cancer Cohort Studies Risk Factors Internal medicine medicine Humans Stomach cancer Aged Gastrointestinal Neoplasms Retrospective Studies stomach cancer business.industry Incidence Cancer Retrospective cohort study Middle Aged medicine.disease Oncology colon cancer Cohort record linkage Cholecystectomy Female business Cohort study |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | We investigated whether cholecystectomy is associated with subsequent cancer and, if so, whether the association is likely to be causal, by undertaking a retrospective cohort study using linked medical statistics, comprising a cholecystectomy group (n=39 254) and a reference cohort admitted for a range of other medical and surgical conditions (n=334 813). We found a short-term significant elevation of rates of cancers of the colon, pancreas, liver, and stomach after cholecystectomy, but no long-term elevation. Excluding colon cancers within 2 years of admission to hospital, the rate ratio for colon cancer after cholecystectomy, compared with the reference cohort, was 1.01 (95% confidence interval 0.90-1.12) and after 10 years or more follow-up it was 0.94 (0.79-1.10). It is highly improbable that the short-term associations between cholecystectomy and gastrointestinal cancers are causal, and we conclude that cholecystectomy does not cause cancer. |
| Databáze: | OpenAIRE |
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