Histomorphologic Observations for Cynomolgus Monkeys after Subchronic Subcutaneous Injection of Recombinant Human Interleukin-4
| Autor: | Kent A. Gossett, Thomas A. Barbolt, Joel B. Cornacoff |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lymphoid Tissue 040301 veterinary sciences Tubular atrophy Hematopoietic System Physiology Genitalia Male Biology Toxicology 030226 pharmacology & pharmacy Muscle Smooth Vascular Pathology and Forensic Medicine 0403 veterinary science 03 medical and health sciences Subcutaneous injection 0302 clinical medicine medicine Animals Humans Vascular Diseases Arteritis Molecular Biology 04 agricultural and veterinary sciences Cell Biology Eosinophil medicine.disease Recombinant Proteins Macaca fascicularis Seminiferous tubule medicine.anatomical_structure Toxicity Blood Vessels Female Interleukin-4 Bone marrow Complication |
| Zdroj: | Toxicologic Pathology. 19:251-257 |
| ISSN: | 1533-1601 0192-6233 |
| DOI: | 10.1177/019262339101900307 |
| Popis: | Recombinant human interleukin-4 (rhuIL-4) is a candidate for the treatment of refractory cancer based on its potential to enhance the function of the immune system. Total daily dosages of 0 (placebo control), 1, 5, or 25 micrograms/kg of rhuIL-4 were given as divided (b.i.d.) subcutaneous dosages to male and female cynomolgus monkeys (5/sex/group) for 1 month followed by a 2-week recovery. Histomorphologic evaluation of 3/sex/group at 1 month revealed vascular lesions, granulocytic hyperplasia, and seminiferous tubular atrophy attributed to treatment with rhuIL-4. Dosage-dependent proliferative and inflammatory vascular lesions with eosinophil infiltration affected principally the arterial tree. After 2 weeks of recovery, these lesions, including chronic endarteritis and chronic and/or obliterative arteritis, occurred with an overall lower incidence, and were not observed for monkeys from the 1.0 micrograms/kg/day group. Granulocytic hyperplasia in bone marrow observed for monkeys from all groups given rhuIL-4 at 1 month was not present after 2 weeks of recovery. Seminiferous tubular atrophy was observed for monkeys from the 5 and 25 micrograms/kg/day groups at 1 month and after 2 weeks of recovery. |
| Databáze: | OpenAIRE |
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