Quantitative assessment of the influence of hematopoietically expressed homeobox variant (rs1111875) on type 2 diabetes risk
| Autor: | Weiwei Qiao, Xianzhe Zhao, Minfang Tao, Yudong Wang |
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| Rok vydání: | 2011 |
| Předmět: |
Candidate gene
Endocrinology Diabetes and Metabolism Hematopoietically expressed homeobox Single-nucleotide polymorphism Genome-wide association study Biology Polymorphism Single Nucleotide Risk Assessment Biochemistry Endocrinology Genetic model Odds Ratio Genetics Genetic predisposition Humans Genetic Predisposition to Disease Allele Molecular Biology Alleles Homeodomain Proteins Odds ratio Hematopoiesis Diabetes Mellitus Type 2 biology.gene Transcription Factors |
| Zdroj: | Molecular Genetics and Metabolism. 102:194-199 |
| ISSN: | 1096-7192 |
| DOI: | 10.1016/j.ymgme.2010.09.013 |
| Popis: | Hematopoietically expressed homeobox (HHEX) gene encodes for a transcription factor involved in Wnt/β-catenin signaling pathway which has attracted considerable attention as a candidate gene for type 2 diabetes (T2D) since it was first identified through genome wide association approach. The relationship between HHEX and T2D has been reported in various ethnic groups; however, these studies have yielded contradictory results. To investigate this inconsistency, we performed a meta-analysis of 26 studies involving a total of 110,875 subjects for rs1111875 of the HHEX gene to evaluate the effect of HHEX on genetic susceptibility for T2D. An overall random effects odds ratio of 1.16 (95% CI: 1.13-1.20) was found for C allele versus T allele. Significant results were also observed using dominant (OR=1.21, 95% CI: 1.16-1.25) or recessive genetic model (OR=1.24, 95% CI: 1.18-1.30). There was strong evidence of heterogeneity (P |
| Databáze: | OpenAIRE |
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