Prostate cancer susceptibility is mediated by interactions between exposure to ultraviolet radiation and polymorphisms in the 5′ haplotype block of the vitamin D receptor gene
| Autor: | Richard C. Strange, Julie Alldersea, Samson Liu, Mark F. Saxby, Anthony A. Fryer, Christopher J. Luscombe, Nicholas J. Rukin, Dhaval Bodiwala, Sam Moon, Paul R. Hoban |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Genetics Cancer Research Haplotype block Base Sequence Genotype Ultraviolet Rays Haplotype Prostatic Neoplasms Single-nucleotide polymorphism PROSTATE CANCER SUSCEPTIBILITY Odds ratio Biology medicine.disease Polymorphism Single Nucleotide Calcitriol receptor Prostate cancer Haplotypes Oncology Cancer research medicine Humans Receptors Calcitriol Ultraviolet radiation DNA Primers |
| Zdroj: | Cancer Letters. 247:328-335 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2006.05.012 |
| Popis: | Vitamin D receptor (VDR) polymorphisms are prostate cancer risk candidates. We determined if SNPs in haplotype block sub-regions C2 (SNPs C2-1, G/C(3436), C2-2, A/G(3944)) or C1 (C1-1, C/T(20965), C1-2, C/T(30056)) are associated with risk in an ultraviolet radiation (UVR)-dependent manner. In men with very low exposure, SNPs in both sub-regions were associated with risk. Various haplotypes in haplotype block C including G(3436)-A(3944)-C(20965)-C(30056), (G or C)-A-C-C and G-A-(C or T)-C were significantly associated with increased risk (odds ratios between 1.95 and 2.37). These findings suggest various block C SNPs are associated with prostate cancer risk via a mechanism involving exposure to sunlight. |
| Databáze: | OpenAIRE |
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