Temporal analysis of HIV envelope sequence evolution and antibody escape in a subtype A-infected individual with a broad neutralizing antibody response
| Autor: | Julie Overbaugh, Stephanie Rainwater, Walter Jaoko, Katherine A. Bosch |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Gene Expression Regulation Viral Envelope sequence evolution HIV Infections HIV Antibodies Biology Article 03 medical and health sciences Phylogenetics Virology Humans Amino Acid Sequence Cloning Molecular Neutralizing antibody Peptide sequence Phylogeny 030304 developmental biology Sequence (medicine) 0303 health sciences 030306 microbiology Antibodies Neutralizing HIV Envelope Protein gp41 3. Good health Antibody response Antibody escape Broad neutralizing antibody response Viral evolution Immunology HIV-1 biology.protein Female Antibody Hiv envelope |
| Zdroj: | Virology. 398:115-124 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2009.11.032 |
| Popis: | The origin of broadly neutralizing HIV-specific antibodies and their relation to HIV evolution are not well defined. Here we examined virus evolution and neutralizing antibody escape in a subtype A infected individual with a broad, cross subtype, antibody response. The majority of envelope variants isolated over the first approximately 5 years after infection were poorly neutralized by contemporaneous plasma that neutralized variants from earlier in infection, consistent with a dynamic process of escape. The majority of variants could be neutralized by later plasma, suggesting these evolving variants may have contributed to the elicitation of new antibody responses. However, some variants from later in infection were recognized by plasma from earlier in infection, including one notably neutralization-sensitive variant that was sensitive due to a proline at position 199 in V2. These studies suggest a complex pattern of virus evolution in this individual with a broad NAb response, including persistence of neutralization-sensitive viruses. |
| Databáze: | OpenAIRE |
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