The Addition of 400 cGY Total Body Irradiation to a Regimen Incorporating Once-Daily Intravenous Busulfan, Fludarabine, and Antithymocyte Globulin Reduces Relapse Without Affecting Nonrelapse Mortality in Acute Myelogenous Leukemia
| Autor: | James A. Russell, Diana Quinlan, Nizar J. Bahlis, Jan Storek, Alexander Balogh, Michelle Geddes, Mary Lynn Savoie, Christopher Brown, Peter Duggan, M. Ahsan Chaudhry, Loree Larratt, A. Robert Turner, Douglas A. Stewart, William Irish, Andrew Daly, Nancy Zacarias |
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| Rok vydání: | 2010 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Adolescent medicine.medical_treatment acute myelogenous leukemia Graft vs Host Disease Hematopoietic stem cell transplantation Myelogenous Young Adult Internal medicine Total body irradiation Antineoplastic Combined Chemotherapy Protocols medicine Animals Humans Busulfan Aged Antilymphocyte Serum Retrospective Studies relapse Transplantation business.industry Hazard ratio Hematopoietic Stem Cell Transplantation Hematology Middle Aged medicine.disease Combined Modality Therapy Fludarabine Surgery Regimen Leukemia Leukemia Myeloid Acute Treatment Outcome Injections Intravenous Female business Vidarabine Whole-Body Irradiation medicine.drug |
| Zdroj: | Biology of Blood and Marrow Transplantation. 16(4):509-514 |
| ISSN: | 1083-8791 |
| DOI: | 10.1016/j.bbmt.2009.11.017 |
| Popis: | A combination of fludarabine (Flu) and daily i.v. busulfan (Bu) is well tolerated and effective in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) for acute myelogenous leukemia (AML). The addition of rabbit antithymocyte globulin (ATG) may reduce morbidity and mortality from graft-versus-host disease (GVHD), but lead to increased relapse. To compensate for this effect, we added 400 cGy of total body irradiation (TBI) to the Flu/Bu regimen in 89 patients, and compared outcomes with those achieved in 90 patients who received the drug combination alone. Although nonrelapse mortality (NRM) at 3 years did not differ between the groups, the inclusion of TBI significantly reduced relapse (hazard ratio [HR] = 0.29; 95% confidence interval [CI] = 0.15-0.54; P = .0001). Consequently, both overall survival (OS; HR = 0.50; 95% CI = 0.3-0.84; P = .009) and disease-free survival (DFS; HR = 0.43; 95% CI = 0.26-0.72; P = .001) were improved with the inclusion of TBI. This study confirms the importance of regimen intensity in allogeneic HSCT for AML. The combination of daily i.v. Bu, Flu, 400 cGy TBI, and ATG provides a well-tolerated regimen with antileukemic activity in AML comparable to that of other, conventional myeloablative (MA) regimens. |
| Databáze: | OpenAIRE |
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