Hypertrophic scars and keloids: a review and current treatment modalities
| Autor: | Sanjeev Tripathi, Rajesh Mondal, Kumud Soni, Vishal Gour, Vandana Soni, Poornima Agrawal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Wound healing Role of HMGB-1in HTS Hypertrophic scar Endocrinological hypothesis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine lcsh:Dermatology Topical drug business.industry General Medicine lcsh:RL1-803 medicine.disease Dermatology Role of growth factors 030104 developmental biology Treatment modality Hypertrophic scarring Drug delivery Hypertrophic scars business Topical Novel DDS |
| Zdroj: | Biomedical Dermatology, Vol 4, Iss 1, Pp 1-11 (2020) |
| ISSN: | 2398-8460 |
| Popis: | Hypertrophic scars (HTS) are raised, red, rigid, inflexible cell-like, and cosmetic problems precipitated due to multiple underlying dermal injuries such as burn, surgery, and trauma during which aberrant wound healing with more pathological deposition of the extracellular matrix than degradation leads to their spawning. Till date, well established and specific treatments for HTS have not been reported; hence, the need of recent developments is thrusted with novel drug delivery vision. This review will try to encompass all the agogs to HTS, definition, pathophysiology, mechanism of hypertrophic scar formation, the role of growth factors in hypertrophic scarring, and their difference with keloids. Further, it will illuminate the available medicaments and recent advances in novel topical drug delivery systems such as ethosomes, transethosomes, liposomes, solid lipid nanoparticles, and microsponges for treatment of HTS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink