Publisher Correction: Electrical coupling between A17 cells enhances reciprocal inhibitory feedback to rod bipolar cells
| Autor: | Felix Leroy, Adrian G. Palacios, Oliver Schmachtenberg, Alex H. Vielma, Claudio Elgueta |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Retinal Bipolar Cells Patch-Clamp Techniques lcsh:Medicine Dark Adaptation Inhibitory postsynaptic potential Synaptic Transmission Retina Feedback Membrane Potentials Rats Sprague-Dawley Text mining Receptors GABA Retinal Rod Photoreceptor Cells Animals Receptors AMPA lcsh:Science Night Vision gamma-Aminobutyric Acid Physics Multidisciplinary business.industry lcsh:R Gap Junctions Publisher Correction Rats Amacrine Cells Synapses ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Biophysics lcsh:Q Calcium Female business Reciprocal |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018) |
| ISSN: | 2045-2322 |
| Popis: | A17 amacrine cells are an important part of the scotopic pathway. Their synaptic varicosities receive glutamatergic inputs from rod bipolar cells (RBC) and release GABA onto the same RBC terminal, forming a reciprocal feedback that shapes RBC depolarization. Here, using patch-clamp recordings, we characterized electrical coupling between A17 cells of the rat retina and report the presence of strongly interconnected and non-coupled A17 cells. In coupled A17 cells, evoked currents preferentially flow out of the cell through GJs and cross-synchronization of presynaptic signals in a pair of A17 cells is correlated to their coupling degree. Moreover, we demonstrate that stimulation of one A17 cell can induce electrical and calcium transients in neighboring A17 cells, thus confirming a functional flow of information through electrical synapses in the A17 coupled network. Finally, blocking GJs caused a strong decrease in the amplitude of the inhibitory feedback onto RBCs. We therefore propose that electrical coupling between A17 cells enhances feedback onto RBCs by synchronizing and facilitating GABA release from inhibitory varicosities surrounding each RBC axon terminal. GJs between A17 cells are therefore critical in shaping the visual flow through the scotopic pathway. |
| Databáze: | OpenAIRE |
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