Intensity-Modulated Radiotherapy is Associated With Improved Global Quality of Life Among Long-term Survivors of Head-and-Neck Cancer
| Autor: | Derick H Lau, Quang Luu, D. Gregory Farwell, James A. Purdy, Allen M. Chen, Esther Vazquez |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Health Status medicine.medical_treatment Locally advanced Young Adult Quality of life medicine Humans Radiology Nuclear Medicine and imaging Survivors Aged Aged 80 and over Anterior neck Chemotherapy Radiation business.industry Head and neck cancer Cancer Middle Aged medicine.disease Quality Improvement Surgery Radiation therapy Oncology Head and Neck Neoplasms Multivariate Analysis Carcinoma Squamous Cell Quality of Life Female Radiotherapy Intensity-Modulated Intensity modulated radiotherapy Radiotherapy Conformal business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 84:170-175 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2011.11.026 |
| Popis: | To compare the long-term quality of life among patients treated with and without intensity-modulated radiotherapy (IMRT) for head-and-neck cancer.The University of Washington Quality of Life instrument scores were reviewed for 155 patients previously treated with radiation therapy for locally advanced head-and-neck cancer. All patients were disease free and had at least 2 years of follow-up. Eighty-four patients (54%) were treated with IMRT. The remaining 71 patients (46%) were treated with three-dimensional conformal radiotherapy (3D CRT) by use of initial opposed lateral fields matched to a low anterior neck field.The mean global quality of life scores were 67.5 and 80.1 for the IMRT patients at 1 and 2 years, respectively, compared with 55.4 and 57.0 for the 3D CRT patients, respectively (p 0.001). At 1 year after the completion of radiation therapy, the proportion of patients who rated their global quality of life as "very good" or "outstanding" was 51% and 41% among patients treated by IMRT and 3DCRT, respectively (p = 0.11). At 2 years, the corresponding percentages increased to 73% and 49%, respectively (p0.001). On multivariate analysis accounting for sex, age, radiation intent (definitive vs. postoperative), radiation dose, T stage, primary site, use of concurrent chemotherapy, and neck dissection, the use of IMRT was the only variable independently associated with improved quality of life (p = 0.01).The early quality of life improvements associated with IMRT not only are maintained but apparently become more magnified over time. These data provide powerful evidence attesting to the long-term benefits of IMRT for head-and-neck cancer. |
| Databáze: | OpenAIRE |
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