Associations between prenatal, childhood, and adolescent stress and variations in white-matter properties in young men
| Autor: | Christopher John Evans, Anja Klasnja, Tomáš Paus, Mark Drakesmith, Sarah K. G. Jensen, Lassi Björnholm, Edward D. Barker, Melissa M. Pangelinan, Alexander Leemans |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Longitudinal study MTR Physiology Review Corpus callosum Adversity Corpus Callosum/diagnostic imaging Corpus Callosum Developmental psychology 0302 clinical medicine Pregnancy Longitudinal Studies Young adult Non-U.S. Gov't Child White Matter/diagnostic imaging Research Support Non-U.S. Gov't White matter Prenatal development Diffusion Tensor Imaging medicine.anatomical_structure Adult Survivors of Child Adverse Events Neurology DTI Prenatal Exposure Delayed Effects Child Preschool Female Psychology Adult Adolescent Cognitive Neuroscience Splenium Research Support Stress Article 03 medical and health sciences Young Adult Diffusion Tensor Imaging/methods Fractional anisotropy medicine MWF Journal Article Humans Preschool Infant 030104 developmental biology Prenatal stress Psychological 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | NeuroImage, 182, 389. Academic Press Inc. Jensen, S K G, Pangelinan, M, Björnholm, L, Klasnja, A, Leemans, A, Drakesmith, M, Evans, C J, Barker, E & Paus, T 2017, ' Associations between prenatal, childhood, and adolescent stress and variations in white-matter properties in young men ', NeuroImage . https://doi.org/10.1016/j.neuroimage.2017.10.033 |
| ISSN: | 1053-8119 |
| DOI: | 10.1016/j.neuroimage.2017.10.033 |
| Popis: | ObjectivePrevious studies have shown that both pre- and post-natal adversities, the latter including exposures to stress during childhood and adolescence, explain variations in structural properties of white matter (WM) in the brain. While previous studies have examined effects of independent stress exposures within one developmental period, such as childhood, we examine effects of stress across development using data from a prospective longitudinal study. More specifically, we ask how stressful events during prenatal development, childhood, and adolescence relate to variation in WM properties in early adulthood in men recruited from a birth cohort.MethodUsing data from 393 mother-son pairs from a community-based birth cohort from England (Avon Longitudinal Study of Parents and Children), we examined how stressful life events relate to variation in different structural properties of WM in the corpus callosum and across the whole brain in early adulthood in men aged 18–21 years. We distinguish between stress occurring during three developmental periods: a) prenatal maternal stress, b) postnatal stress within the first four years of life, c) stress during adolescence (age 12–16 years). To obtain a comprehensive quantification of variation in WM, we assess structural properties of WM using four different measures, namely fractional anisotropy (FA), mean diffusivity (MD), magnetization transfer ratio (MTR) and myelin water fraction (MWF).ResultsThe developmental model shows that prenatal stress is associated with lower MTR and MWF in the genu and/or splenium of the corpus callosum, and with lower MTR in global (lobar) WM. Stress during early childhood is associated with higher MTR in the splenium, and stress during adolescence is associated with higher MTR in the genu and lower MD in the splenium. We see no associations between postnatal stress and variation in global (lobar) WM.ConclusionsThe current study found evidence for independent effects of stress on WM properties during distinct neurodevelopmental periods. We speculate that these independent effects are due to differences in the developmental processes unfolding at different developmental time points. We suggest that associations between prenatal stress and WM properties may relate to abnormalities in neurogenesis, affecting the number and density of axons, while postnatal stress may interfere with processes related to myelination or radial growth of axons. Potential consequences of prenatal glucocorticoid exposure should be considered in obstetric care. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect