HTLV-1-Associated Lymphoma Presented as Massive Lymphadenopathy
Autor: | Rashid Chaudhry, Vijay Jaswani, Gregory Gotlieb, Karan Josan, Pei Ting Chen, Jen-Chin Wang, Cheema Akhtar, David Onukogu |
---|---|
Rok vydání: | 2021 |
Předmět: |
Pathology
medicine.medical_specialty Medicine (General) human T-cell lymphotropic virus type I–associated lymphoma Lymphocytosis Lymphoma Epidemiology Pleural effusion Case Report Malignancy 03 medical and health sciences 0302 clinical medicine R5-920 hemic and lymphatic diseases lymphadenopathy Ascites medicine RB1-214 Humans Leukemia-Lymphoma Adult T-Cell Safety Risk Reliability and Quality 030304 developmental biology Skin 0303 health sciences Gastrointestinal tract Human T-lymphotropic virus 1 Lung business.industry medicine.disease Leukemia medicine.anatomical_structure HTLV-1 030220 oncology & carcinogenesis medicine.symptom business Safety Research |
Zdroj: | Journal of Investigative Medicine High Impact Case Reports Journal of Investigative Medicine High Impact Case Reports, Vol 9 (2021) |
ISSN: | 2324-7096 |
Popis: | Adult T-cell leukemia/lymphoma is an aggressive T-cell malignancy caused by the long-term infection of human T-cell lymphotropic virus type 1 (HTLV-1). Our understanding of clinical features still largely relies on the Shimoyama classification developed 30 years ago, which described the 4 clinical subtypes (the smoldering, chronic, lymphoma, and acute types) based on the manifestations of lymphocytosis, elevated lactate dehydrogenase, hypercalcemia, lymphadenopathy, and involvement of the skin, lung, liver, spleen, central nervous system, bone, ascites, pleural effusion, and gastrointestinal tract. HTLV-1-associated lymphoma has a variety of presentations but the presentation of massive lymphadenopathy and compression symptoms is rare and has not been emphasized in the literature. In this article, we describe 2 cases of adult T-cell leukemia/lymphomas that presented with massive cervical nodes or mediastinal nodes with compressing symptoms as the major presenting clinical features. Clinicians should remain aware of this type of presentation by HTLV-1-associated lymphoma, especially in patients who came from endemic areas, even if not all clinical features are present and particularly with hypercalcemia and lytic bone lesions. |
Databáze: | OpenAIRE |
Externí odkaz: |