Postchemotherapy retroperitoneal residual mass resection for germ cell testicular tumors: a single-center experience
| Autor: | Serdar Kalemci, Fuat Kizilay, Kasim Emre Ergun, Bayram Aliyev, Adnan Simsir |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male General Medicine Retroperitoneal lymph node dissection Neoplasms Germ Cell and Embryonal Positron-Emission-Tomography Lymph-Node Dissection Seminoma Young Adult Testicular Neoplasms Testicular cancer Germ cell tumor Humans Chemotherapy Nonseminoma Retroperitoneal lymph node dissection Retrospective Studies |
| Zdroj: | Revista da Associação Médica Brasileira v.68 n.4 2022 Revista da Associação Médica Brasileira Associação Médica Brasileira (AMB) instacron:AMB Revista da Associação Médica Brasileira, Volume: 68, Issue: 4, Pages: 524-529, Published: 25 MAY 2022 |
| Popis: | SUMMARY Objective: Postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) plays an important role in the management of advanced germ cell testicular tumors. Bilateral template lymph node dissection is considered a standard treatment in postchemotherapy residual masses; however, modified unilateral templates have gained acceptance in patients with unilateral residual disease. In this study, we aimed to demonstrate the perioperative and oncological outcomes of the patients with advanced testicular cancer who underwent unilateral modified template PC-RPLND in our center. Methods: This is a retrospective study in which patients who underwent PC-RPLND in a referred center between 2004 and 2021 were investigated. All patients had three or four cycles of chemotherapy and retroperitoneal residual masses. Data were retrospectively collected from medical, operative, radiology, and pathology records and analyzed. Results: A total of 57 patients underwent PC-RPLND. The mean age was 32.7±8.1 years (19–50). According to the disease stage at presentation, there were 39 patients with stage 2 and 18 patients with stage 3. The average tumor size after chemotherapy was 57.6±2.7 mm (25–117). The overall complication rate was 35% (20/57 patients). No grade 4 and 5 complications were observed. Pathologic review demonstrated the presence of teratoma in 28 (49.1%) patients, fibrosis and/or necrosis in 15 (26.3%) patients, and viable germ cell tumor in 14 (24.5%) patients. The mean follow-up was 69.4 months (8–201). During follow-up after surgery, 14 (24.5%) deaths occurred due to advanced disease. Conclusion: PC-RPLND is a major component of the management of advanced testicular germ cell cancer. Our study demonstrated that modified unilateral template is an effective and safe procedure in the postchemotherapy setting for selected patients. |
| Databáze: | OpenAIRE |
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