Successful Treatment of Life-threatening Bleeding Caused by Acquired Factor X Deficiency Associated with Respiratory Infection
| Autor: | Satoshi Ichikawa, Yuya Tanaka, Yasushi Onishi, Minami Fujiwara, Kei Saito, Yoonha Lee, Koichi Onodera, Hideo Harigae, Noriko Fukuhara, Hisayuki Yokoyama |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Case Report Hemorrhage 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Internal Medicine medicine pneumonia Humans Factor X Deficiency Respiratory Tract Infections Coagulation Disorder Hematuria Prothrombin time medicine.diagnostic_test business.industry Amyloidosis Autoantibody Respiratory infection General Medicine acquired factor X deficiency medicine.disease Pneumonia Coagulation Prothrombin Time 030211 gastroenterology & hepatology Partial Thromboplastin Time Blood Coagulation Tests business severe hematuria Partial thromboplastin time |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | Acquired factor X deficiency (AFXD) is a very rare coagulation disorder. A 40-year-old man with no comorbidities suffering from a fever, malaise, and severe hemorrhagic symptoms, including massive hematuria, was emergently admitted. His platelet count was normal, but his prothrombin time and activated partial thromboplastin time were markedly prolonged, which was thought to be due to autoantibody against a coagulation factor in the common pathway. Despite severe massive hematuria resulting in transient renal failure, he was successfully treated with urgent immunosuppressive therapy. Computed tomography revealed bronchopneumonia, which improved with antibiotic administration. AFXD without evidence of amyloidosis was subsequently diagnosed. |
| Databáze: | OpenAIRE |
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