Antimicrobial Resistance of Non-O157 Shiga Toxin-Producing Escherichia coli Isolated from Humans and Domestic Animals
| Autor: | Hui Sun, Xi Yang, Lijiao Cao, Bin Hu, Yanwen Xiong, Juan Li, Ji Zhang, Xiangning Bai, Dong Jin, Qian Liu, Yanyu Pan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Imipenem Nalidixic acid Tetracycline 030106 microbiology Biology medicine.disease_cause Biochemistry Microbiology STEC infection 03 medical and health sciences Antibiotic resistance multidrug resistance medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Pathogen Escherichia coli Shiga toxin-producing Escherichia coli whole genome sequencing lcsh:RM1-950 Antimicrobial antimicrobial drugs Multiple drug resistance 030104 developmental biology Infectious Diseases lcsh:Therapeutics. Pharmacology medicine.drug |
| Zdroj: | Antibiotics, Vol 10, Iss 74, p 74 (2021) Antibiotics Volume 10 Issue 1 |
| ISSN: | 2079-6382 |
| Popis: | Non-O157 Shiga toxin-producing Escherichia coli (STEC) is an important pathogen that can cause zoonotic diseases. To investigate the antimicrobial resistance of STEC in China, non-O157 STEC isolates, recovered from domestic animals and humans from 12 provinces, were analyzed using antimicrobial susceptibility testing and whole genome characterization. Out of the 298 isolates tested, 115 strains showed resistance to at least one antimicrobial and 85 strains showed multidrug resistance. The highest resistance rate was to tetracycline (32.6%), followed by nalidixic acid (25.2%) and chloramphenicol and azithromycin (both 18.8%). However, imipenem and meropenem were effective against all isolates. Antimicrobial resistance patterns varied among strains from different sources. Strains from pig, sheep, humans, and cattle showed resistance rates of 100.0%, 46.9%, 30.3%, and 6.3% to one or more antimicrobials, respectively. Forty-three genes related to 11 antimicrobial classes were identified among these strains. The colistin-resistance gene mcr was only carried by strains from pigs. A new fosfomycin-resistant gene, fosA7, was detected in strains from humans, cattle, and sheep. Whole genome phylogenetic analysis showed that strains from the four sources were genetically diverse and scattered throughout the phylogenetic tree however, some strains from the same source had a tendency to cluster closely. These results provide a reference to monitor the emergence and spread of multidrug resistant STEC strains among animals and humans. Furthermore, with a better understanding of antimicrobial genotypes and phenotypes among the diverse STEC strains obtained, this study could guide the administration of antimicrobial drugs in STEC infections when necessary. |
| Databáze: | OpenAIRE |
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