Alkylation of isatins with trichloroacetimidates

Autor: Rowan Meador, Nilamber Mate, Bhaskar Joshi, John Chisholm
Rok vydání: 2022
Předmět:
Zdroj: Organic & Biomolecular Chemistry. 20:2131-2136
ISSN: 1477-0539
1477-0520
Popis: N-Alkylation or O-alkylation of isatins can be achieved utilizing trichloroacetimidate electrophiles with the major product being controlled by solvent effects. These reactions provide access to N-alkyl isatins, versatile scaffolds which are often employed in synthesis.
Databáze: OpenAIRE