Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses
| Autor: | Kazuaki Iguchi, Akira Sumiyoshi, Sanae Hasegawa-Ishii, Atsuyoshi Shimada, Keiko Unno, Hiroi Nonaka, Yoriyuki Nakamura, Tomokazu Konishi, Koichi Inoue, Kyoko Taguchi, Yoshio Muguruma, Ryuta Kawashima, Michiko Hayashi |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty hippocampus Hippocampus lcsh:TX341-641 Lipocalin Article 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Atrophy Glutamates Internal medicine medicine Animals Chronic stress Prefrontal cortex chronic stress chemistry.chemical_classification prefrontal cortex Brain Diseases Nutrition and Dietetics Tea SAMP10 Theanine medicine.disease Housing Animal theanine Amino acid MRI analysis 030104 developmental biology Endocrinology chemistry Excitatory postsynaptic potential lcsh:Nutrition. Foods and food supply 030217 neurology & neurosurgery brain atrophy Stress Psychological Food Science |
| Zdroj: | Nutrients Volume 12 Issue 1 Nutrients, Vol 12, Iss 1, p 174 (2020) |
| ISSN: | 2072-6643 |
| Popis: | Chronic stress can impair the health of human brains. An important strategy that may prevent the accumulation of stress may be the consumption of functional foods. When senescence-accelerated mice prone 10 (SAMP10), a stress-sensitive strain, were loaded with stress using imposed male mouse territoriality, brain volume decreased. However, in mice that ingested theanine (6 mg/kg), the main amino acid in tea leaves, brain atrophy was suppressed, even under stress. On the other hand, brain atrophy was not clearly observed in a mouse strain that aged normally (Slc:ddY). The expression level of the transcription factor Npas4 (neuronal PAS domain protein 4), which regulates the formation and maintenance of inhibitory synapses in response to excitatory synaptic activity, decreased in the hippocampus and prefrontal cortex of stressed SAMP10 mice, but increased in mice that ingested theanine. Lipocalin 2 (Lcn2), the expression of which increased in response to stress, was significantly high in the hippocampus and prefrontal cortex of stressed SAMP10 mice, but not in mice that ingested theanine. These data suggest that Npas4 and Lcn2 are involved in the brain atrophy and stress vulnerability of SAMP10 mice, which are prevented by the consumption of theanine, causing changes in the expression of these genes. |
| Databáze: | OpenAIRE |
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