Secondary metabolites from the stems of Engelhardia roxburghiana and their antitubercular activities
| Autor: | Ho-Chen Wu, Ming-Jen Cheng, Chien-Fang Peng, Shyh-Chyun Yang, Hsun-Shuo Chang, Chu-Hung Lin, Chyi-Jia Wang, Ih-Sheng Chen |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Plant Stems
biology Plant Extracts ved/biology Metabolite ved/biology.organism_classification_rank.species Diarylheptanoid Antitubercular Agents Biological activity Microbial Sensitivity Tests Mycobacterium tuberculosis Plant Science General Medicine Horticulture biology.organism_classification Sesquiterpene Biochemistry Juglandaceae chemistry.chemical_compound chemistry Engelhardia roxburghiana Molecular Biology Biological evaluation |
| Zdroj: | Phytochemistry. 82:118-127 |
| ISSN: | 0031-9422 |
| Popis: | Engelharquinone (1), engelharquinone epoxide (2), engelharolide (3), and engelhardic acid (4), were isolated as naturally occurring products from a plant source, Engelhardia roxburghiana together with 20 previously known compounds, four of which were hitherto not known as plant constituents. Their structures were identified by means of spectroscopic analysis. A biological evaluation showed that three of the previously isolated antitubercular constituents [(-)-4-hydroxy-1-tetralone, 3-methoxyjuglone and engelhardione] and engelharquinone (1) exhibited moderate antitubercular activity against Mycobacterium tuberculosis 90-221387. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect