Supplementary Data from Phase II Multicenter Study of Enzalutamide in Metastatic Castration-Resistant Prostate Cancer to Identify Mechanisms Driving Resistance

Autor: Mary-Ellen Taplin, R. Bruce Montgomery, Glenn J. Bubley, Peter S. Nelson, Evan Y. Yu, Rupal S. Bhatt, Eliezer M. Van Allen, Joshua M. Lang, Xiao X. Wei, Zhenwei Zhang, Rosina T. Lis, Lillian Werner, Wanling Xie, Shuang G. Zhao, Jamie M. Sperger, Jett P. Crowdis, Lucia Kwak, Rana R. McKay
Rok vydání: 2023
DOI: 10.1158/1078-0432.22480128
Popis: 1. Supplementary table 1S describing details of biopsies undergoing WES. 2. Table 2S includes the primers used in the CTC gene expression analysis. 3. Table 3S includes summary of PSA response based on prior treatment. 4. Table 4S includes objective response in the overall cohort and based on patients with measurable and non-measurable disease. 5. Table 5S is the PSA progression and radiographic PFS based on prior lines of treatment. 6. Table 6S is the adverse events in >10% of patients. 7. Table 7S is a listing of the biopsy procedures and outcomes. 8. Table 8S is the frequency of genomic alterations in the baseline and progression samples and PSA response data. 9. Table 9S includes the details for the AR mutations observed in the baseline and progression samples. 10. Figure 1S includes the KM curves for PSA progression and radiographic PFS. 11. Figure 2S includes the Consort Diagram for the study. 12. Figure 3S includes the integrative data of paired biopsy and CTC samples. 13. Figure 4S includes the KM curves for time to PSA progression, radiographic PFS, and overall survival in the CTC biomarker groups.
Databáze: OpenAIRE