Regulation of plasminogen activation in rat cell lines
| Autor: | J. J. J. Giezen, P. Kaczmarek, J. W. C. M. Jansen, J. H. Reinders |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Retinoic acid Tretinoin Butyrate Dysgerminoma General Biochemistry Genetics and Molecular Biology Phorbol ester Dexamethasone chemistry.chemical_compound Plasminogen Activators Liver Neoplasms Experimental History and Philosophy of Science Internal medicine 1-Methyl-3-isobutylxanthine Plasminogen Activator Inhibitor 1 medicine Cyclic AMP Tumor Cells Cultured Animals Insulin General Neuroscience Plasminogen Activator Inhibitor Type 1 Liver Neoplasms Rats Endocrinology chemistry Bucladesine Cell culture Tissue Plasminogen Activator Electrophoresis Polyacrylamide Gel Plasminogen activator medicine.drug |
| Zdroj: | Annals of the New York Academy of Sciences. 667 |
| ISSN: | 0077-8923 |
| Popis: | The regulation of plasminogen activators (PA) and their inhibitors (PAI) in the rat cell lines: HTC and L2 was studied. HTC plasminogen activator inhibitor type 1 (PAI-1) production was stimulated by dexamethasone, serum factors and insulin; that of tissue-type plasminogen activator (tPA) by cAMP raising agents. Retinoic acid, butyrate, phorbol ester and endotoxin did not affect net PA/PAI activity elaborated by HTC. L2 cells produced tPA, which production was stimulated by retinoic acid, phorbol myristate acetate, butyrate and cAMP; serum factors blunted their response, whereas in the synthetic serum substituting medium Ultraculture and with cocktail Ultroser the action of tPA stimulators was enhanced. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text