Antiheparin activity in human endothelial cells
| Autor: | Genevieve A. Morelli, Hussain I. Saba, Sabiha R. Saba |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Cytoplasm
biology Endothelium medicine.drug_class Anticoagulant Infant Newborn Heparin Antagonists Hematology Heparin Chemical Fractionation Hydrogen-Ion Concentration Pharmacology Umbilical Cord Endothelial stem cell medicine.anatomical_structure Hemostasis Immunology medicine Major basic protein biology.protein Humans In patient medicine.drug |
| Zdroj: | Thrombosis Research. 42:355-362 |
| ISSN: | 0049-3848 |
| DOI: | 10.1016/0049-3848(86)90264-1 |
| Popis: | Human endothelial cells possess antiheparin activity that neutralizes the anticoagulant action of heparin as measured by different tests of the clotting system. The antiheparin activity appears to be associated with an acid-soluble basic protein present in the particulate fraction of the endothelial cell cytoplasm. This finding might have some relevance in the maintenance of hemostasis. Furthermore, it might also have a pharmacological role in terms of resistance to exogenously infused heparin in patients with throm-boembolic disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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