Guidelines for using proton MR spectroscopy in multicenter clinical MS studies

Autor: Massimo Filippi, Paul M. Matthews, Achim Gass, Christian Enzinger, N. De Stefano, David Miller, Alex Rovira, Douglas L. Arnold, Petra J. W. Pouwels
Přispěvatelé: De Stefano, N, Filippi, Massimo, Miller, Dh, Pouwels, Pj, Rovira, A, Gass, A, Enzinger, C, Matthews, Pm, Arnold, Dl
Jazyk: angličtina
Rok vydání: 2007
Předmět:
APPEARING WHITE-MATTER
Pathology
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Multiple Sclerosis
AXONAL DAMAGE
chemistry.chemical_compound
N-ACETYL-ASPARTATE
In vivo
medicine
Humans
Multicenter Studies as Topic
Choline
Glatiramer acetate
IN-VIVO
GLATIRAMER ACETATE
business.industry
Multiple sclerosis
ABSOLUTE METABOLITE CONCENTRATIONS
Neurodegeneration
Glutamate receptor
MAGNETIC-RESONANCE-SPECTROSCOPY
APPEARING WHITE-MATTER
REMITTING MULTIPLE-SCLEROSIS
N-ACETYL-ASPARTATE
ABSOLUTE METABOLITE CONCENTRATIONS
AXONAL DAMAGE
IN-VIVO
GRAY-MATTER
THALAMIC NEURODEGENERATION
GLATIRAMER ACETATE
GRAY-MATTER
MAGNETIC-RESONANCE-SPECTROSCOPY
medicine.disease
Proton mr spectroscopy
Clinical trial
chemistry
REMITTING MULTIPLE-SCLEROSIS
nervous system
Practice Guidelines as Topic
THALAMIC NEURODEGENERATION
Neurology (clinical)
business
Nuclear medicine
medicine.drug
Zdroj: De Stefano, N, Filippi, M, Miller, D, Pouwels, P J, Rovira, A, Gass, A, Enzinger, C, Matthews, P M & Arnold, D L 2007, ' Guidelines for using proton MR spectroscopy in multicenter clinical MS studies ', Neurology, vol. 69, no. 20, pp. 1942-1952 . https://doi.org/10.1212/01.wnl.0000291557.62706.d3
ISSN: 0028-3878
DOI: 10.1212/01.wnl.0000291557.62706.d3
Popis: Proton MR spectroscopy (MRS) allows noninvasive characterization of chemical-pathologic changes in the brain. In patients with multiple sclerosis (MS), proton MRS reveals chemical pathology in focal inflammatory lesions as well as in regions of the brain that are not associated with structural abnormalities on conventional MRI. In MS studies, it has been particularly useful as a method for the assessment of neurodegeneration based on decreases in the levels of the neuro-axonal marker compound, N-acetylaspartate. Also, MRS has provided evidence of chemical pathology and repair involving non-neuronal brain cells based on changes in metabolites, including choline, myo-inositol, glutamate, and GABA. Despite its greater pathologic specificity for axonal integrity compared to conventional MRI, MRS has been used only infrequently in clinical trials. This prompted us to review current MRS clinical applications in MS, discuss the potential and limitations of the technique, and suggest recommendations for the application of MRS to clinical trials.
Databáze: OpenAIRE
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